Royal Caribbean's humanitarian mission rescued about 2,200 people from San Juan Thursday night.
The cruise line will also pick up hundreds from St. Thomas and 1,000 more from the U.S. Virgin Islands before it reaches Florida next week.
Royal Caribbean canceled its Sept. 30 trip to use the ship to deliver much-needed supplies and help evacuate people from the island.
Royal Caribbean is collecting donations for recovery efforts. To learn more, click here.